Retinal Microvascular Responses to Short-Term Changes in Particulate Air Pollution in Healthy Adults

@article{Louwies2013RetinalMR,
  title={Retinal Microvascular Responses to Short-Term Changes in Particulate Air Pollution in Healthy Adults},
  author={Tijs Louwies and Luc Int Panis and Michal Kicinski and Patrick De Boever and Tim S. Nawrot},
  journal={Environmental Health Perspectives},
  year={2013},
  volume={121},
  pages={1011 - 1016}
}
Background: Microcirculation plays an important role in the physiology of cardiovascular health. Air pollution is an independent risk factor for the development and progression of cardiovascular diseases, but the number of studies on the relation between air pollution and the microcirculation is limited. Objectives: We examined the relationship between short-term changes in air pollution and microvascular changes. Methods: We measured retinal microvasculature using fundus image analysis in a… 
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TLDR
The findings suggest that short-term exposures to traffic-related air pollutants with high oxidative potential are major components contributing to microvascular dysfunction.
Relation of long-term exposure to air pollution to brachial artery flow-mediated dilation and reactive hyperemia.
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Residential proximity to a major roadway and higher levels of spatially resolved estimates of PM2.5 at participant residences are associated with impaired conduit artery and microvascular function in this large community-based cohort of middle-aged and elderly adults.
Particulate Matter and Cardiovascular Disease: Researchers Turn an Eye toward Microvascular Changes
  • J. Barrett
  • Medicine
    Environmental health perspectives
  • 2013
TLDR
Pollution-related changes in the tiny blood vessels of the retina could offer insights into potential impacts on cardiovascular disease risk, and the finding is consistent with downstream effects of air pollution that are already known to lead to atherosclerosis.
Turning an eye towards cardiovascular health: the retina in public health research
TLDR
The changes in the diameters of retinal blood vessels are reported as a measure of the microvascular response to the interventions to conclude that retinal vessel diameters are useful to study the dynamic microv vascular response.
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