Retinal Microvascular Responses to Short-Term Changes in Particulate Air Pollution in Healthy Adults

@article{Louwies2013RetinalMR,
  title={Retinal Microvascular Responses to Short-Term Changes in Particulate Air Pollution in Healthy Adults},
  author={Tijs Louwies and Luc Int Panis and Michal Kicinski and Patrick De Boever and Tim S. Nawrot},
  journal={Environmental Health Perspectives},
  year={2013},
  volume={121},
  pages={1011 - 1016}
}
Background: Microcirculation plays an important role in the physiology of cardiovascular health. Air pollution is an independent risk factor for the development and progression of cardiovascular diseases, but the number of studies on the relation between air pollution and the microcirculation is limited. Objectives: We examined the relationship between short-term changes in air pollution and microvascular changes. Methods: We measured retinal microvasculature using fundus image analysis in a… 
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Background Citations
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Citation Type

Retinal Microvascular Response to Short-Term Exposure to Particulate Matters As an Indicator of Cardiovascular Effects in Work Environments
TLDR
Evaluating the changes in retinal micro vascular responses in workers exposed to short-term exposure to particulate matters caused by occupational processes using CRAE, CRVE, and AVR markers found no significant relationship between retinal artery changes and cardiovascular parameters.
miRNA expression profiles and retinal blood vessel calibers are associated with short-term particulate matter air pollution exposure.
TLDR
PM10 exposure affected miRNAs that are involved in inflammatory and oxidative stress pathways and it is suggested that miRNA changes may be relevant to explain the association between PM10 and retinal vessel calibers.
Blood pressure changes in association with black carbon exposure in a panel of healthy adults are independent of retinal microcirculation.
TLDR
A positive association between blood pressure and subchronic black carbon Exposure in healthy adults is found, adding evidence to the association between black carbon exposure and cardiovascular health effects, with elevated blood pressure as a plausible intermediate effector.
Air pollution and retinal vessel diameter and blood pressure in school-aged children in a region impacted by residential biomass burning
TLDR
The results suggest that outdoor air pollution impacts the retinal microvasculature of children and interactions between PM2.5 and Ox may play an important role in determining the magnitude and direction of these associations.
Short-term exposure to air pollution and digital vascular function.
TLDR
The findings in a community-based sample exposed to relatively low pollution levels suggest that short-term exposure to ambient particulate pollution is not associated with vasodilator response, but that particulate air pollution is associated with baseline pulse amplitude, suggesting potentially adverse alterations in baseline vascular tone or compliance.
Recent versus chronic fine particulate air pollution exposure as determinant of the retinal microvasculature in school children
TLDR
The results suggest that the microcirculation, with retinal microvasculature as a proxy in this study, is a pathophysiological target for air pollution in children.
Associations between microvascular function and short-term exposure to traffic-related air pollution and particulate matter oxidative potential
TLDR
The findings suggest that short-term exposures to traffic-related air pollutants with high oxidative potential are major components contributing to microvascular dysfunction.
Relation of long-term exposure to air pollution to brachial artery flow-mediated dilation and reactive hyperemia.
TLDR
Residential proximity to a major roadway and higher levels of spatially resolved estimates of PM2.5 at participant residences are associated with impaired conduit artery and microvascular function in this large community-based cohort of middle-aged and elderly adults.
Particulate Matter and Cardiovascular Disease: Researchers Turn an Eye toward Microvascular Changes
  • J. Barrett
  • Medicine
    Environmental health perspectives
  • 2013
TLDR
Pollution-related changes in the tiny blood vessels of the retina could offer insights into potential impacts on cardiovascular disease risk, and the finding is consistent with downstream effects of air pollution that are already known to lead to atherosclerosis.
Turning an eye towards cardiovascular health: the retina in public health research
TLDR
The changes in the diameters of retinal blood vessels are reported as a measure of the microvascular response to the interventions to conclude that retinal vessel diameters are useful to study the dynamic microv vascular response.
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