Retinal Microglial Activation Following Topical Application of Intracellular Toll-Like Receptor Ligands.

@article{Chinnery2015RetinalMA,
  title={Retinal Microglial Activation Following Topical Application of Intracellular Toll-Like Receptor Ligands.},
  author={Holly Rose Chinnery and Cecilia Naranjo Golborne and Cheng Mee Leong and Weisan Chen and John V. Forrester and Paul G McMenamin},
  journal={Investigative ophthalmology & visual science},
  year={2015},
  volume={56 12},
  pages={7377-86}
}
PURPOSE We previously have reported that application of the intracellular toll-like receptor (TLR)-9 ligand CpG-ODN onto the injured corneal surface induces widespread inflammation within the eye, including the retina. We tested the hypothesis that topical application of two other intracellular TLR agonists, Poly I:C and R848, would cause retinal microglial activation and migration into the subretinal space. METHODS C57BL/6J wild-type and Cx3cr1gfp/+ mice were anesthetized and received… CONTINUE READING