Retinal Input Directs the Recruitment of Inhibitory Interneurons into Thalamic Visual Circuits

@article{Golding2014RetinalID,
  title={Retinal Input Directs the Recruitment of Inhibitory Interneurons into Thalamic Visual Circuits},
  author={Bruno J D Golding and Gabrielle Pouchelon and Camilla Bellone and Sahana Murthy and Ariel A. Di Nardo and Subashika Govindan and Masahuro Ogawa and Tomomi Shimogori and Christian L{\"u}scher and Alexandre Dayer and Denis Jabaudon},
  journal={Neuron},
  year={2014},
  volume={81}
}
Inhibitory interneurons (INs) critically control the excitability and plasticity of neuronal networks, but whether activity can direct INs into specific circuits during development is unknown. Here, we report that in the dorsal lateral geniculate nucleus (dLGN), which relays retinal input to the cortex, circuit activity is required for the migration, molecular differentiation, and functional integration of INs. We first characterize the prenatal origin and molecular identity of dLGN INs… CONTINUE READING
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