Retinal Architecture and Melanopsin-Mediated Pupillary Response Characteristics: A Putative Pathophysiologic Signature for the Retino-Hypothalamic Tract in Multiple Sclerosis.

@article{Meltzer2017RetinalAA,
  title={Retinal Architecture and Melanopsin-Mediated Pupillary Response Characteristics: A Putative Pathophysiologic Signature for the Retino-Hypothalamic Tract in Multiple Sclerosis.},
  author={Ethan I. Meltzer and Peter V. Sguigna and Adnan M Subei and Shin Chien Beh and Eric J. Kildebeck and Darrel Conger and Amy J. Conger and Marlen Lucero and Benjamin S Frohman and Ashley N. Frohman and Shiv Saidha and Steven L. Galetta and Peter A. Calabresi and Robert L. Rennaker and Teresa C. Frohman and Randy H. Kardon and Laura Balcer and Michael Karl Racke},
  journal={JAMA neurology},
  year={2017},
  volume={74 5},
  pages={
          574-582
        }
}
Importance A neurophysiologic signature of the melanopsin-mediated persistent constriction phase of the pupillary light reflex may represent a surrogate biomarker for the integrity of the retinohypothalamic tract, with potential utility for investigating alterations in homeostatic mechanisms associated with brain disorders and implications for identifying new treatments. Objective To characterize abnormalities of retinal architecture in patients with multiple sclerosis (MS) and corresponding… CONTINUE READING