Retina-specific T regulatory cells bring about resolution and maintain remission of autoimmune uveitis.

@article{Silver2015RetinaspecificTR,
  title={Retina-specific T regulatory cells bring about resolution and maintain remission of autoimmune uveitis.},
  author={Phyllis B. Silver and Reiko Horai and Jun Chen and Yingyos Jittayasothorn and Chi-Chao Chan and Rafael Villasmil and Muge R. Kesen and Rachel R Caspi},
  journal={Journal of immunology},
  year={2015},
  volume={194 7},
  pages={3011-9}
}
Experimental autoimmune uveitis (EAU) induced in mice by immunization with the retinal Ag interphotoreceptor retinoid-binding protein (IRBP) is a model of human autoimmune uveitis. We examined whether T regulatory cells (Tregs) found in uveitic eyes are IRBP specific, functionally suppressive, and play a role in natural resolution of disease and in maintenance of remission. Progressive increase of Foxp3(+) Treg to T effector cell (Teff) ratio in uveitic eyes correlated with resolution of… CONTINUE READING