Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels.

@article{Wickenden2000RetigabineAN,
  title={Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels.},
  author={A. Wickenden and W. Yu and A. Zou and T. Jegla and P. Wagoner},
  journal={Molecular pharmacology},
  year={2000},
  volume={58 3},
  pages={
          591-600
        }
}
Retigabine [N-(2-amino-4-[fluorobenzylamino]-phenyl) carbamic acid; D-23129] is a novel anticonvulsant, unrelated to currently available antiepileptic agents, with activity in a broad range of seizure models. In the present study, we sought to determine whether retigabine could enhance current through M-like currents in PC12 cells and KCNQ2/Q3 K(+) channels expressed in Chinese hamster ovary cells (CHO-KCNQ2/Q3). In differentiated PC12 cells, retigabine enhanced a linopirdine-sensitive current… Expand
272 Citations
Activation of Expressed KCNQ Potassium Currents and Native Neuronal M-Type Potassium Currents by the Anti-Convulsant Drug Retigabine
  • 357
  • Highly Influenced
  • PDF
M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body β-Hydroxybutyrate
  • 6
  • PDF
Retigabine Stimulates Human KCNQ2/Q3 Channels in the Presence of Bupivacaine
  • 9
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation
  • 78
Activation of KCNQ5 channels stably expressed in HEK293 cells by BMS-204352.
  • 61
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells.
  • C. Rundfeldt
  • Chemistry, Medicine
  • European journal of pharmacology
  • 1997
  • 158
  • Highly Influential
Characterization of the K+ channel opening effect of the anticonvulsant retigabine in PC12 cells
  • 42
  • Highly Influential
Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons.
  • 122
  • PDF
Retigabine strongly reduces repetitive firing in rat entorhinal cortex.
  • 39
Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by 4-aminopyridine in rat entorhinal cortex hippocampal slices
  • 55
Inhibition of M-type K+ current by linopirdine, a neurotransmitter-release enhancer, in NG108-15 neuronal cells and rat cerebral neurons in culture
  • 21
  • Highly Influential
D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures
  • 216
D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures.
  • 133
...
1
2
3
4
...