Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes.

@article{Stavnezer1989ReticulumCS,
  title={Reticulum cell sarcomas of SJL mice have rearranged immunoglobulin heavy and light chain genes.},
  author={Janet Stavnezer and J L Lasky and Nicholas M. Ponzio and Michael P. Scheid and G. Jeanette Thorbecke},
  journal={European journal of immunology},
  year={1989},
  volume={19 6},
  pages={1063-9}
}
The immunoglobulin (Ig) heavy (H) and light (L) chain gene rearrangements of the high incidence SJL lymphomas (reticulum cell sarcoma, RCS) have been analyzed. Both primary and transplanted RCS show rearrangements of H and kappa L chains, demonstrating that these tumors are of B cell origin. These data are consistent with previous results indicating that… CONTINUE READING