Reticulon 4a/NogoA locates to regions of high membrane curvature and may have a role in nuclear envelope growth

@inproceedings{Kiseleva2007Reticulon4L,
  title={Reticulon 4a/NogoA locates to regions of high membrane curvature and may have a role in nuclear envelope growth},
  author={Elena V. Kiseleva and Ksenia N Morozova and Gia K. Voeltz and Terrence D. Allen and Martin W. Goldberg},
  booktitle={Journal of structural biology},
  year={2007}
}
Reticulon 4a (Rtn4a) is a membrane protein that shapes tubules of the endoplasmic reticulum (ER). The ER is attached to the nuclear envelope (NE) during interphase and has a role in post mitotic/meiotic NE reassembly. We speculated that Rtn4a has a role in NE dynamics. Using immuno-electron microscopy we found that Rtn4a is located at junctions between membranes in the cytoplasm, and between cytoplasmic membranes and the outer nuclear membrane in growing Xenopus oocyte nuclei. We found that… CONTINUE READING

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