Reticulocalbin 3 Deficiency in Alveolar Epithelium Exacerbated Bleomycin-induced Pulmonary Fibrosis.

@article{Jin2018Reticulocalbin3D,
  title={Reticulocalbin 3 Deficiency in Alveolar Epithelium Exacerbated Bleomycin-induced Pulmonary Fibrosis.},
  author={Jiawei Jin and Xiaoqian Shi and Yongchao Li and Qianyu Zhang and Yu Guo and Chaokun Li and Pingping Tan and Qiuhong H Fang and Yingmin Ma and Runlin Z. Ma},
  journal={American journal of respiratory cell and molecular biology},
  year={2018},
  volume={59 3},
  pages={
          320-333
        }
}
Reticulocalbin 3 (Rcn3) is an endoplasmic reticulum (ER) lumen protein localized to the secretory pathway. We have reported that Rcn3 plays a critical role in alveolar epithelial type II cell maturation during perinatal lung development, but its biological role in the adult lung is largely unknown. In this study, we found marked induction of Rcn3 expression in alveolar epithelium during bleomycin-induced pulmonary fibrosis, which is most obvious in alveolar epithelial type II cells (AECIIs). To… CONTINUE READING