Reticulin fibres anchor leukaemic blasts in the marrow of patients with acute lymphoblastic leukaemia.

@article{Nath2011ReticulinFA,
  title={Reticulin fibres anchor leukaemic blasts in the marrow of patients with acute lymphoblastic leukaemia.},
  author={Shriram Vaidia Nath and Ian Nicholson and Heather Tapp and Heddy Zola and Andrew C W Zannettino and Tamas R Revesz},
  journal={Medical hypotheses},
  year={2011},
  volume={77 3},
  pages={333-5}
}
Reticulin fibrosis has been recognized in childhood ALL at diagnosis as part of the altered stromal structure in the bone marrow (BM). Increased fibre density is correlated with a higher concentration of leukaemia cells in the BM and lower numbers of blasts in peripheral blood. We hypothesize that these fibres anchor the leukaemia cells within the BM in close proximity to BM stromal cells (BMSC). The BMSC are a rich source of growth factors and cytokines which enhance leukaemia cell growth and… CONTINUE READING

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