Rethinking genetic models of asthma: the role of environmental modifiers.

  title={Rethinking genetic models of asthma: the role of environmental modifiers.},
  author={Carole Ober and Emma E. Thompson},
  journal={Current opinion in immunology},
  volume={17 6},
Asthma is a common, chronic disease with a complex etiology. To date, more than 35 genes have been associated with asthma or related phenotypes in multiple populations, but none of them has been shown to contribute to risk in all populations studied. We suggest that genetic susceptibility is both context dependent and developmentally regulated, and that ignoring the environmental context will miss many important associations and clues to pathogenesis. We define 'environment' broadly to include… CONTINUE READING

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