Rethinking Models of Psychotropic Drug Action

@article{Moncrieff2005RethinkingMO,
  title={Rethinking Models of Psychotropic Drug Action},
  author={Joanna Moncrieff and David Cohen},
  journal={Psychotherapy and Psychosomatics},
  year={2005},
  volume={74},
  pages={145 - 153}
}
Theoretical assumptions about how psychotropic drugs ‘work’ are rarely discussed explicitly. In a ‘disease-centred model,’ drugs are believed to work by acting on a disease process. In contrast, in a ‘drug-centred model,’ the characteristic physiological, behavioural and subjective effects of drugs are used to define drug action. The therapeutic value of a drug stems from the usefulness of these effects in clinical situations. The disease-centred model appears dominant but has weaknesses: (1… 
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