Rethinking Differentiation: Stem Cells, Regeneration, and Plasticity

@article{Alvarado2014RethinkingDS,
  title={Rethinking Differentiation: Stem Cells, Regeneration, and Plasticity},
  author={Alejandro S{\'a}nchez Alvarado and Shinya Yamanaka},
  journal={Cell},
  year={2014},
  volume={157},
  pages={110-119}
}
Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it means to be a stem or a differentiated cell. Past and recent discoveries in plants and animals, as well as novel experimental manipulations, are beginning to erode many of these… CONTINUE READING

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