Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane

Abstract

Membrane cholesterol–sphingolipid ‘rafts’, which are characterized by their insolubility in the non-ionic detergent Triton X-100 in the cold, have been implicated in the sorting of certain membrane proteins, such as placental alkaline phosphatase (PLAP), to the apical plasma membrane domain of epithelial cells. Here we show that prominin, an apically sorted… (More)
DOI: 10.1038/35023524

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