Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

@inproceedings{Zhou2017RetentionON,
  title={Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes},
  author={Zhengqiu Zhou and Adam D. Bachstetter and Claudia B. Sp{\"a}ni and Saktimayee Mitra Roy and D Martin Watterson and Linda J. Van Eldik},
  booktitle={Journal of Neuroinflammation},
  year={2017}
}
Brain p38α mitogen-activated protein kinase (MAPK), a potential therapeutic target for cognitive dysfunction based on the neuroinflammation-synaptic dysfunction cycle of pathophysiology progression, offers an innovative pharmacological strategy via inhibiting the same activated target in both glia and neurons, thereby enhancing the possibility for efficacy. The highly selective, brain-penetrant p38αMAPK inhibitor MW150 attenuates cognitive dysfunction in two distinct Alzheimer’s disease (AD… CONTINUE READING
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