Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF.

@article{Tsutsumi2001RetentionOM,
  title={Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF.},
  author={Shinji Tsutsumi and Atsushi Shimazu and Kazuko Miyazaki and Haiou Pan and Chika Koike and Eiko Yoshida and K. Takagishi and Yu Kato},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={288 2},
  pages={413-9}
}
Mesenchymal stem cells (MSC) that can differentiate to various connective tissue cells may be useful for autologous cell transplantation to defects of bone, cartilage, and tendon, if MSC can be expanded in vitro. However, a short life span of MSC and a reduction in their differentiation potential in culture have limited their clinical application. The purpose of this study is to identify a growth factor(s) involved in self-renewal of MSC and the maintenance of their multilineage differentiation… CONTINUE READING
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