Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleen.

@article{Safeukui2008RetentionOP,
  title={Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleen.},
  author={Innocent Safeukui and J. Correas and Valentine Brousse and D{\'e}borah Hirt and Guillaume Deplaine and S{\'e}bastien Mul{\'e} and Micka{\"e}l Lesurtel and Nicolas Goasguen and Alain Sauvanet and Anne Couvelard and Sophie Kern{\'e}is and Huot Khun and In{\`e}s Vigan-Womas and Catherine Ottone and Thierry Jo Molina and J M Tr{\'e}luyer and Odile Mercereau-Puijalon and Genevi{\`e}ve Milon and Peter H. David and Pierre A Buffet},
  journal={Blood},
  year={2008},
  volume={112 6},
  pages={2520-8}
}
The current paradigm in Plasmodium falciparum malaria pathogenesis states that young, ring-infected erythrocytes (rings) circulate in peripheral blood and that mature stages are sequestered in the vasculature, avoiding clearance by the spleen. Through ex vivo perfusion of human spleens, we examined the interaction of this unique blood-filtering organ with P falciparum-infected erythrocytes. As predicted, mature stages were retained. However, more than 50% of rings were also retained and… CONTINUE READING
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