Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice.

@article{Fukaya2003RetentionON,
  title={Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice.},
  author={Masahiro Fukaya and Akira Kato and Chanel Lovett and Susumu Tonegawa and Masahiko Watanabe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 8},
  pages={4855-60}
}
Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system, and the N-methyl-D-aspartate-selective glutamate receptor (NR) consisting of the NR1 subunit and an NR2 or NR3 subunit plays crucial roles in synaptic transmission, plasticity, and learning and memory. By using a knockout mouse strain, in which the NR1 gene deletion is primarily targeted to the CA1 pyramidal cells of the hippocampus, we investigated the in vivo effect of the loss of the NR1 subunit on the… CONTINUE READING

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