Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma.

@article{Zeelenberg2001RetentionOC,
  title={Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a T cell hybridoma.},
  author={Ingrid S. Zeelenberg and L Ruuls-Van Stalle and Emelie Roos},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={108 2},
  pages={269-77}
}
The dissemination of T cell hybridomas to multiple nonhematopoietic tissues is blocked by pertussis toxin, suggesting the involvement of a chemokine. To study whether this chemokine is SDF-1, we employed a strategy proposed previously for gene therapy of AIDS, whereby the SDF-1 receptor CXCR4 (also a coreceptor for HIV) is retained in the endoplasmic reticulum (ER) and fails to reach the cell surface. We transfected SDF-1, carrying an ER retention sequence, into a T cell hybridoma. This altered… CONTINUE READING

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