Retaspimycin hydrochloride (IPI-504): a novel heat shock protein inhibitor as an anticancer agent.

@article{Hanson2009RetaspimycinH,
  title={Retaspimycin hydrochloride (IPI-504): a novel heat shock protein inhibitor as an anticancer agent.},
  author={Britt Erika Hanson and David H Vesole},
  journal={Expert opinion on investigational drugs},
  year={2009},
  volume={18 9},
  pages={
          1375-83
        }
}
Heat shock proteins are vital to cell survival under conditions of stress. They bind client proteins to assist in protein stabilization, translocation of polypeptides across cell membranes and recovery of proteins from aggregates. Heat shock protein inhibitors are a diverse group of novel agents that have been demonstrated to have pro-apoptotic effects on malignant cells through inhibition of ATP binding on the ATP/ADP-binding pocket of the heat shock protein. Initial development of heat shock… CONTINUE READING
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