Retargeting pre-existing human antibodies to a bacterial pathogen with an alpha-Gal conjugated aptamer

Abstract

The ever-increasing threat of multi-drug resistant bacterial infections has spurred renewed interest in alternative approaches to classical antibiotic therapy. In contrast to other mammals, humans do not express the galactose-α-1,3-galactosyl-β-1,4-N-acetyl-glucosamine (α-Gal) epitope. As a result of exposure of humans to α-Gal in the environment, a large… (More)
DOI: 10.1007/s00109-015-1280-4

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