Retardation of the age-related increase in spontaneous cortical spike-wave discharges (SWD) in rats after a 28-day inhalation (SWD) in rats after a 28-day inhalation exposure to an industrial solvent, pseudocumene (1,2,4-trimethylbenzene).

@article{Gralewicz1997RetardationOT,
  title={Retardation of the age-related increase in spontaneous cortical spike-wave discharges (SWD) in rats after a 28-day inhalation (SWD) in rats after a 28-day inhalation exposure to an industrial solvent, pseudocumene (1,2,4-trimethylbenzene).},
  author={Sławomir Gralewicz and Dorota Wiaderna and Tadeusz Tomas},
  journal={International journal of occupational medicine and environmental health},
  year={1997},
  volume={10 2},
  pages={213-22}
}
It has been hypothesized that exposure to neurotoxins may hasten the process of brain ageing. Volatile hydrocarbons are in common use as solvents and their neurotoxic properties are acknowledged. In the rat, the age-related neurodegenerative changes in the brain develop together with an increased occurrence of bursts of spontaneous spike-wave discharges (SWD) in the neocortex. Therefore, the number and/or duration of SWD bursts may serve as an index allowing to distinguish between young and old… CONTINUE READING
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