Retardation of fracture healing by cerclage wire near the elbow in radius fracture models.

Abstract

Cerclage wire is widely used in the treatment of fracture internal fixation and is shown effective in clinic. But a report by S.L. has pointed that the wire loop delayed the growth of bone. We have established a radius fracture model to study the possible detrimental effects of cerclage wire on fracture healing and the potential mechanism. By high-resolution CT analysis cerclage wire is found to delay fracture healing, by histological assessment cerclage wire is found to extended the time of hematoma and the marrow cavity appearing, by confocal microscopy cerclage wire decreased the content of calcium and the expression of alkaline phosphatase (ALP), and by RT-PCR analysis cerclage wire decreased the mRNA levels of bone sialoprotein and ALP. These results suggest that the cerclage wire near the elbow delayed the fracture healing in radius fracture models.

DOI: 10.1016/j.rvsc.2015.12.002

Cite this paper

@article{Liu2016RetardationOF, title={Retardation of fracture healing by cerclage wire near the elbow in radius fracture models.}, author={Fangning Liu and Bin Li and Haiyu Wang and Qinghe Han and Guoxi Shao and Yingjie Gao and Guanghong Xie}, journal={Research in veterinary science}, year={2016}, volume={104}, pages={58-63} }