Retardation of coronary artery disease in humans by the calcium-channel blocker nifedipine: Results of the INTACT study (International Nifedipine Trial on Antiatherosclerotic Therapy)

@article{Lichtlen1990RetardationOC,
  title={Retardation of coronary artery disease in humans by the calcium-channel blocker nifedipine: Results of the INTACT study (International Nifedipine Trial on Antiatherosclerotic Therapy)},
  author={Prof. Dr. Paul R. Lichtlen and Paul G. Hugenholtz and Wolfgang Rafflenbeul and Hartmut Hecker and Stefan Jost and Peter Nikutta and Jaap Willem Deckers},
  journal={Cardiovascular Drugs and Therapy},
  year={1990},
  volume={4},
  pages={1047-1068}
}
Experimental studies have demonstrated a 30–50% reduction in the development of atheromatous lesions of the aorta in rabbits fed a diet rich in cholesterol when they were treated wity nifedipine. Based on these favorable results, we designed a multicenter, placebo (PL)-controlled, randomized, double-blind study, to test the effect of 80 mg nifedipine (NIF) per day versus placebo on the progression of mild coronary artery disease (CAD) (further development of existing stenoses, especially… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Retarda - tion of angiogn ' aphic progression of coronary artery disease by nifedipine

  • PR Lichtlen, PG Hugenholtz, W Rafflenbeul
  • La ttcet
  • 1990

Calcium antagonists and ACAT inhibitors promote cholesterol efflux fiom macrophages by different mechanisms

  • G Schmitz, H Robinek, M Beuck
  • I : Arteriosclerosis
  • 1988

Clinical application of quantitative corona W angiography - - Preliminary results of the [ NTACT - Study ( International Nifedipine Trial on Anti - atherosclerotic Therapy )

  • S lost, J Deckers, U Nellessen
  • 1988

Inhibitory effect of calcium antagonists on balloon catheter induced arterial smooth muscle cell proliferation and lesion size

  • J JacksonL, RC Bush, DE Bowyer
  • Arterioscle - rosis
  • 1988

Similar Papers

Loading similar papers…