Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions.

@article{Shimizu1996RetardationOC,
  title={Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions.},
  author={Shigeomi Shimizu and Yutaka Eguchi and Wataru Kamiike and Satoshi Waguri and Yasuo Uchiyama and Hikaru Matsuda and Yoshihide Tsujimoto},
  journal={Oncogene},
  year={1996},
  volume={12 10},
  pages={2045-50}
}
Inhibition of the respiratory chain reaction by cyanide, rotenone or antimycin A (chemical hypoxia) induces necrotic cell death characterized by apparently intact chromatin, remarkable mitochondrial swelling with loss of crista structure, and loss of plasma membrane integrity. The treatments induce no apoptotic cell death, as defined by fragmented nuclei with condensed chromatin, fragmented or condensed cytoplasm. The anti-apoptotic proteins Bcl-2 and Bcl-xL effectively retard the chemical… CONTINUE READING

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