Resveratrol vs. calorie restriction: Data from rodents to humans

@article{Lam2013ResveratrolVC,
  title={Resveratrol vs. calorie restriction: Data from rodents to humans},
  author={Yan Y. Lam and Courtney M Peterson and Eric Ravussin},
  journal={Experimental Gerontology},
  year={2013},
  volume={48},
  pages={1018-1024}
}

Figures and Tables from this paper

Calorie restriction and sirtuins revisited.

TLDR
A great body of new data in the sirtuin field is drawn that shows a systematic redirection of mammalian physiology in response to diet by sirtuins, and the prospects for drugs that can deliver at least a subset of the benefits of CR seems very real.

Promoting healthspan and lifespan with caloric restriction in primates

TLDR
Efforts should be made in combining nutrition-based clinical protocols with therapeutic and/or behavioral interventions to aim for synergetic effects, and therefore delay the onset of age-related diseases without adverse effects.

The consequences of a high-calorie diet background before calorie restriction on skeletal muscles in a mouse model

TLDR
Empirical evidence is presented showing significant interactions between HCD (4 months) and CR (3 months), and it is theorized that the effects of CR may vary according to the physiologic, metabolic, and genetic peculiarities of the skeletal muscle described here and that INTM/IM lipid infiltration and tissue-specific fuel-energy status (demand/ supply) both hold dependent-interacting roles with other key anti-aging mechanisms triggered by CR.

Can restricting calories help you to live longer?

TLDR
This review critically evaluates the benefits of daily calorie restriction or intermittent fasting periods on age-related decline and longevity in human populations.

Comparison of Calorie-Restricted Diet and Resveratrol Supplementation on Anthropometric Indices, Metabolic Parameters, and Serum Sirtuin-1 Levels in Patients With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial

TLDR
CR diet with moderate weight loss has favorable effects on NAFLD, and resveratrol supplementation induced weight loss but failed to mimic other aspects of CR diet.

Comparative effects of energy restriction and resveratrol intake on glycemic control improvement

TLDR
Mild energy restriction is more efficient than intake of RSV within a standard balanced diet, and acts by means of a different mechanism from that of RSR, which shows an improvement in all the markers related to glycemic control.

The Effects of Resveratrol Supplementation in Overweight and Obese Humans: A Systematic Review of Randomized Trials.

TLDR
There is currently insufficient evidence to support the recommendation of resveratrol supplements in management of obesity, however, there were significant but not entirely consistent anti-inflammatory effects after resver atrol supplementation in overweight and obese individuals.

Lack of Additive Effects of Resveratrol and Energy Restriction in the Treatment of Hepatic Steatosis in Rats

TLDR
The results show that resveratrol is useful for liver steatosis treatment within a balanced diet, although its effectiveness is lower than that of energy restriction.

Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates

  • V. RobertsL. Pound K. Grove
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2014
TLDR
It is demonstrated that resveratrol use during pregnancy yields improvements in maternal and placental phenotype with beneficial effects in the fetal liver but an unexplained and concerning alteration in fetal pancreatic development, which strongly cautions against the use of resver atrol by pregnant women.
...

References

SHOWING 1-10 OF 114 REFERENCES

Effects of Chronic Calorie Restriction or Dietary Resveratrol Supplementation on Insulin Sensitivity Markers in a Primate, Microcebus murinus

TLDR
It is suggested that both CR and RSV have beneficial effects on metabolic alterations, although these effects are different in amplitude between the two anti-aging treatments and potentially rely on different metabolic changes.

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

TLDR
Resveratrol, at doses that can be readily achieved in humans, fulfills the definition of a dietary compound that mimics some aspects of CR, andGene expression profiling suggests that both CR and resver atrol may retard some aspect of aging through alterations in chromatin structure and transcription.

Calorie restriction, SIRT1 and metabolism: understanding longevity

TLDR
Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.

Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation

TLDR
CR provided superior protection against diet-induced obesity and fatty liver formation as compared to resveratrol, and the effects were associated with increased physical activity and ameliorated adipose tissue inflammation.

Resveratrol improves health and survival of mice on a high-calorie diet

TLDR
It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.

Resveratrol treatment in mice does not elicit the bradycardia and hypothermia associated with calorie restriction

TLDR
It is concluded that the bradycardia and hypothermia associated with calorie restriction occur through mechanisms unaffected by the actions of resveratrol and that further studies are needed to examine the differential effects of res veratrol in a leptin‐deficient background.

Development of Calorie Restriction Mimetics as a Prolongevity Strategy

Abstract: By applying calorie restriction (CR) at 30‐50% below ad libitum levels, studies in numerous species have reported increased life span, reduced incidence and delayed onset of age‐related
...