Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.

@article{Tth2014ResveratrolTR,
  title={Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase.},
  author={Peter T{\'o}th and Stefano Tarantini and Zsuzsanna Tucsek and Nicole M. Ashpole and Danuta Sosnowska and Tripti Gautam and Praveen Ballabh and A. E. Koller and William Edmund Sonntag and Anna Csisz{\'a}r and Zoltan Ungvari},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2014},
  volume={306 3},
  pages={H299-308}
}
Moment-to-moment adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling is essential for the maintenance of normal neuronal function. Increased oxidative stress that occurs with aging was shown to impair neurovascular coupling, which likely contributes to a significant age-related decline in higher cortical function, increasing the risk for vascular cognitive impairment. Resveratrol is a polyphenolic compound that exerts significant antiaging protective effects… CONTINUE READING