Resveratrol treatment rescues hyperleptinemia and improves hypothalamic leptin signaling programmed by maternal high-fat diet in rats.

@article{Franco2016ResveratrolTR,
  title={Resveratrol treatment rescues hyperleptinemia and improves hypothalamic leptin signaling programmed by maternal high-fat diet in rats.},
  author={Juliana Gast{\~a}o Franco and Camilla P Dias-Rocha and T{\^a}nia A P Fernandes and L Albuquerque Maia and P C Lisb{\^o}a and E G Moura and Carmen Cabanelas Pazos-Moura and Isis Hara Trevenzoli},
  journal={European journal of nutrition},
  year={2016},
  volume={55 2},
  pages={601-610}
}
PURPOSE Perinatal high-fat diet is associated with obesity and metabolic diseases in adult offspring. Resveratrol has been shown to exert antioxidant and anti-obesity actions. However, the effects of resveratrol on leptinemia and leptin signaling are still unknown as well as whether resveratrol treatment can improve metabolic outcomes programmed by maternal high-fat diet. We hypothesize that resveratrol treatment in male rats programmed by high-fat diet would decrease body weight and food… CONTINUE READING
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