Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase

@article{Pandey2010ResveratrolSG,
  title={Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase},
  author={P. R. Pandey and H. Okuda and M. Watabe and S. K. Pai and W. Liu and A. Kobayashi and F. Xing and K. Fukuda and S. Hirota and T. Sugai and G. Wakabayashi and K. Koeda and M. Kashiwaba and K. Suzuki and T. Chiba and M. Endo and T. Fujioka and S. Tanji and Y. Mo and D. Cao and A. Wilber and K. Watabe},
  journal={Breast Cancer Research and Treatment},
  year={2010},
  volume={130},
  pages={387-398}
}
Resveratrol is a natural polyphenolic compound and has been shown to exhibit cardio-protective as well as anti-neoplastic effects on various types of cancers. However, the exact mechanism of its anti-tumor effect is not clearly defined. Resveratrol has been shown to have strong hypolipidemic effect on normal adipocytes and as hyper-lipogenesis is a hallmark of cancer cell physiology, the effect of resveratrol on lipid synthesis in cancer stem-like cells (CD24−/CD44+/ESA+) that were isolated… Expand
144 Citations
Antitumor effects of curcumin: A lipid perspective
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells.
Resveratrol suppresses prostate cancer progression in transgenic mice.
Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation.
Inhibition of Fatty-acid Synthase Induces Caspase-8-mediated Tumor Cell Apoptosis by Up-regulating DDIT4*
Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells.
...
1
2
3
4
5
...