Resveratrol suppresses TGF-β-induced VEGF synthesis in osteoblasts: Inhibition of the p44/p42 MAPKs and SAPK/JNK pathways.

@article{Kuroyanagi2015ResveratrolST,
  title={Resveratrol suppresses TGF-β-induced VEGF synthesis in osteoblasts: Inhibition of the p44/p42 MAPKs and SAPK/JNK pathways.},
  author={Gen Kuroyanagi and Takanobu Otsuka and Naohiro Yamamoto and Rie Matsushima-Nishiwaki and Osamu Kozawa and Haruhiko Tokuda},
  journal={Experimental and therapeutic medicine},
  year={2015},
  volume={9 6},
  pages={
          2303-2310
        }
}
Resveratrol, which is found in grape and berry skins and red wine, is generally known to be beneficial for human health due to its anti-inflammation and antioxidant effects. We have recently reported that transforming growth factor-β (TGF-β) stimulates vascular endothelial growth factor (VEGF) synthesis through Smad-independent pathways, such as the p38 mitogen-activated protein (MAP) kinase, p44/p42 MAP kinase and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) pathways, in… CONTINUE READING

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