Resveratrol supplementation abrogates pro-arteriogenic effects of intramyocardial vascular endothelial growth factor in a hypercholesterolemic swine model of chronic ischemia.

@article{Chu2011ResveratrolSA,
  title={Resveratrol supplementation abrogates pro-arteriogenic effects of intramyocardial vascular endothelial growth factor in a hypercholesterolemic swine model of chronic ischemia.},
  author={L. Chu and Michael P. Robich and Antonio D. Lassaletta and Jun Feng and R. Laham and Thomas A. Burgess and R. Clements and F. Sellke},
  journal={Surgery},
  year={2011},
  volume={150 3},
  pages={
          390-9
        }
}
BACKGROUND Clinical trials of therapeutic angiogenesis with vascular endothelial growth factor (VEGF) have been disappointing, owing likely to endothelial dysfunction. We used a swine model of chronic ischemia and endothelial dysfunction to determine whether resveratrol coadministration would improve the angiogenic response to VEGF therapy. METHODS Yorkshire swine fed a high-cholesterol diet underwent left circumflex ameroid constrictor placement, and were given either no drug (high… Expand
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