Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells.

@article{Mizutani1998ResveratrolST,
  title={Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells.},
  author={K. Mizutani and K. Ikeda and Y. Kawai and Y. Yamori},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={253 3},
  pages={
          859-63
        }
}
Nutritional and pharmacological factors are needed to prevent bone loss that occurs with increasing age. The chemical compounds that act on bone metabolism as nutrients in food, however, are poorly understood. The effect of resveratrol, a natural phytoestrogen, on the proliferation and differentiation of osteoblastic MC3T3-E1 cells was studied. Resveratrol dose-dependently increased DNA synthesis (10(-9)-10(-7) M) of MC3T3-E1 cells. In addition, resveratrol increased alkaline phosphatase (ALP… Expand
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Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor.
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