Resveratrol-salicylate derivatives as selective DNMT3 inhibitors and anticancer agents.

@article{Aldawsari2016ResveratrolsalicylateDA,
  title={Resveratrol-salicylate derivatives as selective DNMT3 inhibitors and anticancer agents.},
  author={Fahad S. Aldawsari and Rodrigo Aguayo-Ortiz and Kanishk Kapilashrami and Jakyung Yoo and Minkui Luo and Jos{\'e} L. Medina-Franco and Carlos A Vel{\'a}zquez-Mart{\'i}nez},
  journal={Journal of enzyme inhibition and medicinal chemistry},
  year={2016},
  volume={31 5},
  pages={695-703}
}
Resveratrol is a natural polyphenol with plethora of biological activities. Resveratrol has previously shown to decrease DNA-methyltransferase (DNMT) enzymes expression and to reactivate silenced tumor suppressor genes. Currently, it seems that no resveratrol analogs have been developed as DNMT inhibitors. Recently, we reported the synthesis of resveratrol-salicylate derivatives and by examining the chemical structure of these analogs, we proposed that these compounds could exhibit DNMT… CONTINUE READING

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