• DOI:10.1152/ajpregu.00308.2014
Corpus ID: 15505280

Resveratrol restored Nrf2 function, reduced renal inflammation, and mitigated hypertension in spontaneously hypertensive rats.

@article{Javkhedkar2015ResveratrolRN,
  title={Resveratrol restored Nrf2 function, reduced renal inflammation, and mitigated hypertension in spontaneously hypertensive rats.},
  author={Apurva A. Javkhedkar and Y. Quiroz and B. Rodriguez-Iturbe and N. Vaziri and M. Lokhandwala and A. A. Banday},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2015},
  volume={308 10},
  pages={
          R840-6
        }
}

Apurva A. Javkhedkar, Y. Quiroz, +3 authors A. A. Banday

Published 2015

Medicine

American journal of physiology. Regulatory, integrative and comparative physiology

Compelling evidence supports the role of oxidative stress and renal interstitial inflammation in the pathogenesis of hypertension. Resveratrol is a polyphenolic stilbene, which can lower oxidative stress by activating the transcription factor nuclear factor-E2-related factor-2 (Nrf2), the master regulator of numerous genes encoding antioxidant and phase II-detoxifying enzymes and molecules. Given the role of oxidative stress and inflammation in the pathogenesis of hypertension, we conducted… CONTINUE READING

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