Resveratrol restored Nrf2 function, reduced renal inflammation, and mitigated hypertension in spontaneously hypertensive rats.

@article{Javkhedkar2015ResveratrolRN,
  title={Resveratrol restored Nrf2 function, reduced renal inflammation, and mitigated hypertension in spontaneously hypertensive rats.},
  author={Apurva A. Javkhedkar and Y. Quiroz and B. Rodriguez-Iturbe and N. Vaziri and M. Lokhandwala and A. A. Banday},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2015},
  volume={308 10},
  pages={
          R840-6
        }
}
  • Apurva A. Javkhedkar, Y. Quiroz, +3 authors A. A. Banday
  • Published 2015
  • Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • Compelling evidence supports the role of oxidative stress and renal interstitial inflammation in the pathogenesis of hypertension. Resveratrol is a polyphenolic stilbene, which can lower oxidative stress by activating the transcription factor nuclear factor-E2-related factor-2 (Nrf2), the master regulator of numerous genes encoding antioxidant and phase II-detoxifying enzymes and molecules. Given the role of oxidative stress and inflammation in the pathogenesis of hypertension, we conducted… CONTINUE READING
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