Resveratrol regulates the cell viability promoted by 17β-estradiol or bisphenol A via down-regulation of the cross-talk between estrogen receptor α and insulin growth factor-1 receptor in BG-1 ovarian cancer cells.

@article{Kang2013ResveratrolRT,
  title={Resveratrol regulates the cell viability promoted by 17β-estradiol or bisphenol A via down-regulation of the cross-talk between estrogen receptor α and insulin growth factor-1 receptor in BG-1 ovarian cancer cells.},
  author={Nam-Hee Kang and Kyung-A. Hwang and Hye-Rim Lee and Dal-Woong Choi and Kyung-Chul Choi},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2013},
  volume={59},
  pages={373-9}
}
Endocrine disrupting chemicals (EDCs) and estrogens appear to promote development of estrogen-dependent cancers, including breast and ovarian carcinomas. In this study, we evaluated the cell viability effect of BPA on BG-1 human ovarian cancer cells, along with the growth inhibitory effect of resveratrol (trans-3,4,5-trihydroxystilbene; RES), a naturally occurring phytoestrogen. In addition, we investigated the underlying mechanism(s) of BPA and RES in regulating the interaction between… CONTINUE READING

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