Resveratrol regulates insulin-like growth factor-II in breast cancer cells.

@article{Vyas2005ResveratrolRI,
  title={Resveratrol regulates insulin-like growth factor-II in breast cancer cells.},
  author={Sharda Vyas and Y. Asmerom and D. D. De Le{\'o}n},
  journal={Endocrinology},
  year={2005},
  volume={146 10},
  pages={
          4224-33
        }
}
IGF-II is a potent mitogen and inhibitor of apoptosis in breast cancer. Regulation of IGF-II is complex and includes inhibition by tumor suppressors, stimulation by oncogenes, and imprinting and hormonal regulation by estrogens. Resveratrol (RSV) is a phytoestrogen that displays estrogen-like agonistic and antagonistic activity. Recent studies have shown that RSV inhibits the growth of breast cancer cells and may represent a potent agent in chemopreventive therapy. Because 17beta-estradiol… Expand
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