Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner.

@article{FischerPosovszky2010ResveratrolRH,
  title={Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner.},
  author={Pamela Fischer-Posovszky and Vera Kukulus and Daniel Tews and Thomas Unterkircher and Klaus-Michael Debatin and Simone Fulda and Martin Wabitsch},
  journal={The American journal of clinical nutrition},
  year={2010},
  volume={92 1},
  pages={5-15}
}
BACKGROUND Caloric restriction leads to retardation of the aging processes and to longer life in many organisms. This effect of caloric restriction can be mimicked by resveratrol, a natural plant product present in grapes and red wine, which is known as a potent activator of sirtuin 1 [silent mating type information regulation 2 homolog 1 (Sirt1)]. OBJECTIVES One main effect of caloric restriction in mammals is a reduction of body fat from white adipose tissue. We sought to identify the… CONTINUE READING
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