Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and apoptotic insults to mouse cerebrovascular endothelial cells.

@article{Lin2010ResveratrolPA,
  title={Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and apoptotic insults to mouse cerebrovascular endothelial cells.},
  author={Yi-Ling Lin and Huai-Chia Chang and T Chen and Jin-Han Chang and Wen-Ta Chiu and Jia-Wei Lin and Ruei-Ming Chen},
  journal={The Journal of nutrition},
  year={2010},
  volume={140 12},
  pages={2187-92}
}
Cerebrovascular endothelial cells (CEC) comprise the blood-brain barrier (BBB). In a previous study, we showed that oxidized LDL (oxLDL) can induce apoptosis of mouse CEC. Resveratrol possesses chemopreventive potential. This study aimed to evaluate the effects of resveratrol on oxLDL-induced insults to mouse CEC and its possible mechanisms. Exposure of mouse CEC to 200 μmol/L oxLDL for 1 h did not cause cell death but significantly altered the permeability and transendothelial electrical… CONTINUE READING