Resveratrol protects against methotrexate-induced hepatic injury in rats.

  title={Resveratrol protects against methotrexate-induced hepatic injury in rats.},
  author={T Tunali-Akbay and Ozer Sehirli and Fer{\'i}ha Ercan and G{\"o}ksel Şener},
  journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  volume={13 2},
PURPOSE The aim of this study to investigate the possible protective effect of resveratrol on some liver and serum/plasma parameters in methotrexate induced toxicity in rats. Methotrexate is used widely to treat various neoplastic diseases such as acute lymphoblastic leukemia, lymphoma, solid cancers, and autoimmune diseases. We hypothesized that resveratrol has a potential to decrease the oxidant damage in MTX-induced hepatic injury. METHODS Following a single dose of methotrexate (20 mg/kg… CONTINUE READING