Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary

@article{Morita2012ResveratrolPE,
  title={Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary},
  author={Yoshihiro Morita and Osamu Wada-Hiraike and Tetsu Yano and Akira Shirane and Mana Hirano and Haruko Hiraike and Satoshi Koyama and Hajime Oishi and Osamu Yoshino and Yuichiro Miyamoto and Kenbun Sone and Katsutoshi Oda and Shunsuke Nakagawa and Kazuyoshi Tsutsui and Yuji Taketani},
  journal={Reproductive Biology and Endocrinology : RB\&E},
  year={2012},
  volume={10},
  pages={14 - 14}
}
BackgroundResveratrol is a natural polyphenolic compound known for its beneficial effects on energy homeostasis, and it also has multiple properties, including anti-oxidant, anti-inflammatory, and anti-tumor activities. Recently, silent information regulator genes (Sirtuins) have been identified as targets of resveratrol. Sirtuin 1 (SIRT1), originally found as an NAD+-dependent histone deacetylase, is a principal modulator of pathways downstream of calorie restriction, and the activation of… 
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Findings propose novel, physiologically relevant roles for SIRT1 in downregulating EDN2 and survival of hGLCs and via deacetylation of histone H3 at the EDn2 promoter, inducing a repressive histone configuration.
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