Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats.

  title={Resveratrol prevents monocrotaline-induced pulmonary hypertension in rats.},
  author={Anna Csisz{\'a}r and Nazar Labinskyy and Susan Olson and John Thomas Pinto and Sachin Gupte and Joseph M. Wu and Furong Hu and Praveen Ballabh and Andrej Podlutsky and Gy{\"o}rgy Losonczy and Rafael C. de Cabo and Rajamma Mathew and Michael S. Wolin and Zoltan Ungvari},
  volume={54 3},
Proliferation of pulmonary arterial smooth muscle cells, endothelial dysfunction, oxidative stress, and inflammation promotes the development of pulmonary hypertension. Resveratrol is a polyphenolic compound that exerts antioxidant and anti-inflammatory protective effects in the systemic circulation, but its effects on pulmonary arteries remain poorly defined. The present study was undertaken to investigate the efficacy of resveratrol to prevent pulmonary hypertension. Rats injected with… CONTINUE READING


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