Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells.

@article{Papoutsis2010ResveratrolPE,
  title={Resveratrol prevents epigenetic silencing of BRCA-1 by the aromatic hydrocarbon receptor in human breast cancer cells.},
  author={Andreas J. Papoutsis and Sarah D K Lamore and Georg T Wondrak and Ornella I. Selmin and Donato F. Romagnolo},
  journal={The Journal of nutrition},
  year={2010},
  volume={140 9},
  pages={
          1607-14
        }
}
The BRCA-1 protein is a tumor suppressor involved in repair of DNA damage. Epigenetic mechanisms contribute to its reduced expression in sporadic breast tumors. Through diet, humans are exposed to a complex mixture of xenobiotics and natural ligands of the aromatic hydrocarbon receptor (AhR), which contributes to the etiology of various types of cancers. The AhR binds xenobiotics, endogenous ligands, and many natural dietary bioactive compounds, including the phytoalexin resveratrol (Res). In… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 47 CITATIONS

Epigenetics: a new link between nutrition and cancer.

  • Nutrition and cancer
  • 2013
VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Similar Papers

Loading similar papers…