Resveratrol modulates interleukin-1β-induced phosphatidylinositol 3-kinase and nuclear factor κB signaling pathways in human tenocytes.

@article{Busch2012ResveratrolMI,
  title={Resveratrol modulates interleukin-1β-induced phosphatidylinositol 3-kinase and nuclear factor κB signaling pathways in human tenocytes.},
  author={Franziska Busch and Ali Mobasheri and Parviz Shayan and Cora Lueders and Ralf Stahlmann and Mehdi Shakibaei},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 45},
  pages={
          38050-63
        }
}
Resveratrol, an activator of histone deacetylase Sirt-1, has been proposed to have beneficial health effects due to its antioxidant and anti-inflammatory properties. However, the mechanisms underlying the anti-inflammatory effects of resveratrol and the intracellular signaling pathways involved are poorly understood. An in vitro model of human tenocytes was used to examine the mechanism of resveratrol action on IL-1β-mediated inflammatory signaling. Resveratrol suppressed IL-1β-induced… CONTINUE READING
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