Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner.

@article{Gatz2008ResveratrolMD,
  title={Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner.},
  author={Susanne Andrea Gatz and Marlen Keimling and Cindy Baumann and Thilo D{\"o}rk and K -M Debatin and Simone Fulda and Lisa Wiesm{\"u}ller},
  journal={Carcinogenesis},
  year={2008},
  volume={29 3},
  pages={519-27}
}
Resveratrol (RV) inhibits tumour initiation, promotion and progression which has mainly been explained by its properties in cell cycle control and apoptosis induction. So far, ambiguous observations have been published regarding its influence on genomic stability. To study RV's effects on DNA double-strand break (DSB) repair, we applied the established enhanced green fluorescent protein (EGFP)- and I-SceI-based assay system on RV-treated lymphoblastoid cell lines (LCLs). We show that RV… CONTINUE READING
15 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…