Resveratrol-mediated downregulation of Rictor attenuates autophagic process and suppresses UV-induced skin carcinogenesis.

@article{Back2012ResveratrolmediatedDO,
  title={Resveratrol-mediated downregulation of Rictor attenuates autophagic process and suppresses UV-induced skin carcinogenesis.},
  author={Jung Ho Back and Yucui Zhu and Alyssa Calabro and Craig Queenan and Audrey Sunwha Kim and Joshua Arbesman and Arianna Kim},
  journal={Photochemistry and photobiology},
  year={2012},
  volume={88 5},
  pages={1165-72}
}
Macroautophagy is a cellular response to various environmental stresses that ensures lysosomal degradation of long-lived and damaged proteins and cellular organelles. It occurs through the formation of an autophagosome, which then fuses with a lysosome to form an autolysosome. Depending on the cellular context, autophagy may promote cancer cell survival or it may serve as a mechanism of tumor suppression. Herein, we show that resveratrol, a natural phytoalexin, induces premature senescence in… CONTINUE READING
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