Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation.

@article{Mauthe2011ResveratrolmediatedAR,
  title={Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation.},
  author={Mario Mauthe and Anke Jacob and Sandra Nicole Freiberger and Katharina Hentschel and York-Dieter Stierhof and Patrice Codogno and Tassula Proikas-Cezanne},
  journal={Autophagy},
  year={2011},
  volume={7 12},
  pages={1448-61}
}
Canonical autophagy is positively regulated by the Beclin 1/phosphatidylinositol 3-kinase class III (PtdIns3KC3) complex that generates an essential phospholipid, phosphatidylinositol 3-phosphate (PtdIns(3)P), for the formation of autophagosomes. Previously, we identified the human WIPI protein family and found that WIPI-1 specifically binds PtdIns(3)P, accumulates at the phagophore and becomes a membrane protein of generated autophagosomes. Combining siRNA-mediated protein downregulation with… CONTINUE READING