Resveratrol-mediated SIRT-1 Interactions with p300 Modulate Receptor Activator of NF-κB Ligand (RANKL) Activation of NF-κB Signaling and Inhibit Osteoclastogenesis in Bone-derived Cells

@inproceedings{Shakibaei2011ResveratrolmediatedSI,
  title={Resveratrol-mediated SIRT-1 Interactions with p300 Modulate Receptor Activator of NF-κB Ligand (RANKL) Activation of NF-κB Signaling and Inhibit Osteoclastogenesis in Bone-derived Cells},
  author={Mehdi Shakibaei and Constanze Buhrmann and Ali Mobasheri},
  booktitle={The Journal of biological chemistry},
  year={2011}
}
Resveratrol is a polyphenolic phytoestrogen that has been shown to exhibit potent anti-oxidant, anti-inflammatory, and anti-catabolic properties. Increased osteoclastic and decreased osteoblastic activities result in bone resorption and loss of bone mass. These changes have been implicated in pathological processes in rheumatoid arthritis and osteoporosis. Receptor activator of NF-κB ligand (RANKL), a member of the TNF superfamily, is a major mediator of bone loss. In this study, we… CONTINUE READING

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Resveratrol Inhibits Osteoclastogenesis 11504 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • W. S. Simonet, D. L. Lacey, C. R. Dunstan, M. Kelley, M. S. Chang
  • APRIL
  • 2011

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