Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells.

@article{FerryDumazet2002ResveratrolIT,
  title={Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells.},
  author={H. Ferry-Dumazet and O. Garnier and M. Mamani-Matsuda and J. Vercauteren and F. Belloc and Christian Billiard and M. Dupouy and D. Thiolat and J. Kolb and G. Marit and J. Reiffers and M. Mossalayi},
  journal={Carcinogenesis},
  year={2002},
  volume={23 8},
  pages={
          1327-33
        }
}
It is often postulated that trans-3,4',5-trihydroxystilbene (resveratrol, RES) exhibits cell growth regulatory and chemopreventive activities. However, mechanisms by which this polyphenol inhibits tumor cell growth, and its therapeutic potential are poorly understood. Using various human leukemia cells, we have first defined the anti-tumoral doses of this compound. RES inhibited the proliferation and induced the apoptosis of all tested lymphoid and myeloid leukemia cells with IC(50) = 5-43… Expand
Resveratrol-induced apoptosis in human T-cell acute lymphoblastic leukaemia MOLT-4 cells.
TLDR
It is demonstrated unequivocally that RES induces apoptosis by inhibiting the Notch pathway and markedly influencing the operation of the interacting apoptosis pathways mediated by p53 and PI3K/Akt. Expand
Caspase mediated enhanced apoptotic action of cyclophosphamide- and resveratrol-treated MCF-7 cells.
TLDR
It is found that RES significantly enhances the caspase-mediated cytotoxic activity of CPA on MCF-7 cells in vitro, suggesting the possibility of a new combination chemotherapeutic regimen leading to improvements in the treatment of breast cancer. Expand
Resveratrol induces apoptosis, influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo.
TLDR
Findings indicate that resveratrol inhibits proliferation, induces apoptosis, and influences cell cycle of L1210 cells in a dose- and time-dependent manner in vitro and in vivo, and can exert adose-related regulatory effect on both innate and specific immune function to L 1210-bearing mice. Expand
Antiproliferative effect of resveratrol in human prostate carcinoma cells.
TLDR
Resveratrol has a strong potential for development as an agent for the prevention of human prostate cancer and is found to correlate with an activation of caspase-3 and caspases-9. Expand
Resveratrol and quercetin-induced apoptosis of human 232B4 chronic lymphocytic leukemia cells by activation of caspase-3 and cell cycle arrest
TLDR
It is shown for the first time that resveratrol and quercetin might block CLL growth through inducing apoptosis and cell cycle arrest through induction of caspase-3 activity. Expand
Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade.
TLDR
It is indicated that RSVL antiproliferative effects on osteosarcoma cells are mediated by the activation of the ERKs/p53 signaling pathway and therefore identifies new targets for strategies to treat and/or prevent osteosARcoma. Expand
Flavones and polyphenols inhibit the NO pathway during apoptosis of leukemia B-cells.
TLDR
In conclusion, inhibition of the NO pathway during apoptosis of leukemia B-cells appears a common mechanism for several compounds belonging to two distinct families of phytoalexins, the flavones and grape-derived polyphenols. Expand
Evaluation of antitumor effects of two vine stalk oligomers of resveratrol on a panel of lymphoid and myeloid cell lines: comparison with resveratrol.
TLDR
Results show that epsilon-viniferin and, more importantly, miyabenol C represent potent antitumor agents that require further investigation, either alone or in combination with resveratrol. Expand
Implication of unfolded protein response in resveratrol-induced inhibition of K562 cell proliferation.
TLDR
It is shown that RES caused cell cycle arrest and proliferation inhibition via induction of unfolded protein response (UPR) in human leukemia K562 cell line, showing the important role of PERK/eIF2alpha branch of UPR in RES-induced inhibition of cell proliferation. Expand
Differential sensitivity to resveratrol-induced apoptosis of human chronic myeloid (K562) and acute lymphoblastic (HSB-2) leukemia cells.
TLDR
Investigation of the in vitro effects of resveratrol on apoptotic pathway in human chronic myeloid and acute lymphoblastic leukemia cells indicated that RES commitment to apoptosis in both cell lines is independent from the intracellular content of glutathione, while it is associated with either the enhanced expression of Bax and cytochrome c release. Expand
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Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cells
Resveratrol (3,5,4′-trihydroxy-trans-stilbene), in the concentration range of 20 μM and above, induced arrest in the S-phase and apoptosis in the T cell-derived T-ALL lymphocytic leukemia cell lineExpand
Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells.
TLDR
A general mechanism of apoptosis induction by resveratrol in ALL cells that involves a mitochondria/caspase-9-specific pathway for the activation of the caspase cascade and is independent of CD95-signaling is pointed to. Expand
Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells.
TLDR
It is found that resveratrol reduces viability and DNA synthesis capability of cultured human promyelocytic leukemia (HL-60) cells and is suggested to have cancer therapeutic as well as chemopreventive potential. Expand
Resveratrol selectively inhibits leukemia cells: a prospective agent for ex vivo bone marrow purging
TLDR
The potential use of resveratrol for ex vivo pharmacological purging of leukemia cells from bone marrow autografts without significant loss in the hematopoietic activity of progenitor cells is indicated. Expand
Resveratrol arrests the cell division cycle at S/G2 phase transition.
TLDR
It is demonstrated that resveratrol causes a complete and reversible cell cycle arrest at the S phase checkpoint, indicating that the G1 --> S transition occurs normally. Expand
Resveratrol induces Fas signalling‐independent apoptosis in THP‐1 human monocytic leukaemia cells
TLDR
It is demonstrated that resveratrol inhibits the growth of THP‐1 human monocytic leukaemia cells in a dose‐dependent manner with a median effective dose of 12 μm and that it may be a potential chemotherapeutic agent for the control of acute monocytes/macrophages. Expand
Anthracyclines trigger apoptosis of both G0 G1 and cycling peripheral blood lymphocytes and induce massive deletion of mature T and B cells
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The data indicate that anthracyclines may induce major peripheral T-cell deletion, a property not shared by many cytotoxic agents, and a rapid production of ceramides. Expand
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TLDR
Melarsoprol may inhibit the growth of lymphoid leukemic cell by promoting programmed cell death in chronic B-cell lymphoproliferative disorders by causing dose- and time-dependent inhibition of survival and growth. Expand
Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase.
TLDR
The results provide a molecular rationale for the role of a potent chemopreventive compound in blocking the initiation of inflammation and oncogenesis and explain aspects of the so-called "French paradox" that is associated with reduced mortality from coronary heart disease and certain cancers. Expand
Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells.
TLDR
Resveratrol caused a significant decrease of ornithine decarboxylase (ODC) activity, a key enzyme of polyamine biosynthesis, which is enhanced in cancer growth, and resulted in the reduction of the intracellular putrescine content, indicating that polyamines might represent one of several targets involved in the anti-proliferative effects of resver atrol. Expand
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