Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells.

  title={Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells.},
  author={H{\'e}l{\`e}ne Ferry-Dumazet and Olivier Garnier and Maria Mamani-Matsuda and Joseph Vercauteren and Françis Belloc and Christian Billiard and Maryse Dupouy and Denis Thiolat and Jean Pierre Kolb and Gerald Marit and Josy Reiffers and M. Djavad Mossalayi},
  volume={23 8},
It is often postulated that trans-3,4',5-trihydroxystilbene (resveratrol, RES) exhibits cell growth regulatory and chemopreventive activities. However, mechanisms by which this polyphenol inhibits tumor cell growth, and its therapeutic potential are poorly understood. Using various human leukemia cells, we have first defined the anti-tumoral doses of this compound. RES inhibited the proliferation and induced the apoptosis of all tested lymphoid and myeloid leukemia cells with IC(50) = 5-43… 

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