Resveratrol inhibits reproductive toxicity induced by deoxynivalenol

  title={Resveratrol inhibits reproductive toxicity induced by deoxynivalenol},
  author={Adriana Koles{\'a}rov{\'a} and Marcela Capcarova and Nora Maruniakov{\'a} and Norbert Luk{\'a}{\vc} and Renata E Ciereszko and Alexander V. Sirotkin},
  journal={Journal of Environmental Science and Health, Part A},
  pages={1329 - 1334}
The aim of this in vitro study was to examine the release of progesterone by porcine ovarian granulosa cells (GCs) after exposure to toxic concentrations of deoxynivalenol (DON), resveratrol (RSV), and their combination (DON with RSV). Ovarian granulosa cells were incubated without (control) or with treatments of natural substances at various doses for 24 h: RSV (10, 30 and 50 μg/mL) / DON (2000, 3000 and 5000 ng/mL), and their combination (10 μg/mL of RSV with 2000 ng/mL of DON; 30 μg/mL of… 
The effect of resveratrol on porcine ovarian granulosa cell functions.
The results suggest a direct effect of resveratrol on proliferation, apoptosis and steroidogenesis in porcine ovaries and data suggest that resver atrol can affect reproductive (ovarian) functions of pigs.
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The results indicate that the stimulatory effect of amygdalin combined with DON on the progesterone release was clearly caused by the DON addition, not by the presence Amygdalin per se, and suggest a possible involvement of both natural substances into the processes of steroidogenesis and appear to be endocrine modulators of porcine ovaries.
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Co-administration of amygdalin and deoxynivalenol disrupted regulatory proteins linked to proliferation of porcine ovarian cells in vitro
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The effect of deoxynivalenol on the secretion activity, proliferation and apoptosis of porcine ovarian granulosa cells in vitro
The dose-dependent association of DON on porcine ovarian functions is suggested and expression of markers of proliferation (cyclin B1 and PCNA) but not on the expression of marker of apoptosis (caspase-3) in porcines granulosa cells is suggested.
In vitro study on the effects of lead and mercury on porcine ovarian granulosa cells
Results indicate that Pb can affect the pathway of proliferation and apoptosis of porcine ovarian granulosa cells through intracellular substances such as cyclin B1 and caspase–3.
Phytoestrogen Resveratrol Suppresses Steroidogenesis by Rat Adrenocortical Cells by Inhibiting Cytochrome P450 c21-Hydroxylase
Resveratrol suppresses corticosterone production by primary rat adrenocortical cell cultures in vitro and ex vivo by inhibiting cytochrome P450 c21-hydroxylase.
Effects of Fusarium mycotoxins on steroid production by porcine granulosa cells.
Effects of a trichothecene, T-2 toxin, on proliferation and steroid production by porcine granulosa cells.
Effects of resveratrol on proliferation and apoptosis in rat ovarian theca-interstitial cells.
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Mechanisms of deoxynivalenol-induced gene expression and apoptosis
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In vitro exposure to low trichothecene concentrations upregulates expression both transcriptionally and post-transcriptionally of cytokines, chemokines and inflammatory genes with concurrent immune stimulation, whereas exposure to high concentrations promotes leukocyte apoptosis with concomitant immune suppression.
Effects of resveratrol analogs on steroidogenesis and mitochondrial function in rat Leydig cells in vitro
The inhibitory actions of resveratrol analogs on steroidogenesis in Leydig cells indicate novel mechanisms of action of these compounds, which may be of potential therapeutic interest, where suppression of androgen action is needed.
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