Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways.

@article{Kim2006ResveratrolIP,
  title={Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways.},
  author={Arianna Kim and Yucui Zhu and Huijie Zhu and Lydia Han and Levy Kopelovich and David R. Bickers and Mohammad Athar},
  journal={Experimental dermatology},
  year={2006},
  volume={15 7},
  pages={
          538-46
        }
}
Resveratrol (trans-3,4',5-trihydroxystilbene) is a naturally occurring polyphenolic phytoalexin found in grapes, and has been shown to inhibit the growth of various types of cancer cells. We investigated the mechanism of the antiproliferative effect of resveratrol in A431-transformed keratinocytes harbouring mutant p53, and show that it is accompanied by G1 cell cycle arrest, which coincides with a marked inhibition of G1 cell cycle regulatory proteins, including cyclins A and D1 and cyclin… CONTINUE READING

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